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s4S SOLUTION™

The Foundation of Skin Longevity

Just as sunscreen helps slow skin aging caused by external damage, s4S SOLUTION™ supports skin at the cellular level to slow aging from within.

It is a freeze-dried, cell-derived composition delivering 2,000+ bioactive factors from fibroblast-derived secretome.

s4S SOLUTION™ is designed to slow biological processes associated with skin aging, supporting long-term skin longevity.

s4S SOLUTION™ is registered with the FDA.

s4S SOLUTION vial and box

Key Benefits

  • Visibly improves skin tone and texture
  • Boosts hydration and glow
  • Helps reduce the appearance of acne scars and fine lines
  • 100% clean, skin cell-derived formula
  • No harsh chemicals, synthetic growth factors, hormones, blood, or DNA

Ingredients

Our product consists of 100% dermal fibroblast conditioned media (hDF-CM). It contains a naturally secreted spectrum of bioactive molecules that play a central role in skin repair, regeneration, and prevention.

Growth Factors Found in s4S SOLUTION™

  • VEGF (Vascular Endothelial Growth Factor): Enhances microcirculation by stimulating the formation of new capillaries; improves oxygen and nutrient delivery to the skin.

  • b-FGF (basic Fibroblast Growth Factor): Strongly promotes the synthesis of collagen, elastin, and glycosaminoglycans; supports skin density, elasticity, and structural integrity.
  • EGF (Epidermal Growth Factor): Stimulates keratinocyte proliferation and differentiation; accelerates wound healing and helps smooth fine lines.
  • Angiogenin: Encourages vascular remodeling and angiogenesis; plays a key role in tissue regeneration and long-term skin vitality.
VEGF Growth Factor
b-FGF Growth Factor
VEGF and b-FGF secretion levels are higher in fibroblast spheroids cultured with FECS™ technology compared to conventional 2D or other 3D methods.
IL-8 cytokine
Fibroblasts cultured with FECS™ technology secrete significantly higher levels of IL-8 and IL-6 compared to conventional 2D and other 3D systems.
IL-6 Cytokine

Cytokines & Immunomodulators

  • IL-6, IL-8, GM-CSF: Modulate inflammatory responses; help calm irritated skin and maintain balance.

  • Anti-inflammatory mediators: Reduce redness, irritation, and promote overall skin comfort.

Peptides & Structural Proteins

  • Collagen-derived peptides: Act as signaling molecules that stimulate new collagen synthesis.

  • Elastin and laminin fragments: Support extracellular matrix organization; improve firmness and elasticity.

  • Tissue inhibitors of metalloproteinases (TIMPs): Prevent excessive collagen breakdown, preserving skin structure.

epidermal thickness increases
Histological analysis demonstrates increased epidermal thickness in skin tissue after treatment with fibroblast conditioned media, primed by FECS™ technology.

Extracellular Vesicles & Exosomes

  • Deliver microRNAs, proteins, and lipids that enhance intercellular communication.

  • Promote wound healing, barrier reinforcement, and skin longevity effects at the cellular level.

In-house testing using nanoparticle tracking analysis (NTA) shows that s4S SOLUTION™ contains a high concentration of nanoscale extracellular vesicles within the typical exosome size range.

Importantly, our vesicles are not only present, they are functionally active. In vitro studies on dermal fibroblasts demonstrate enhanced cell proliferation when cultured with FECS™ Technology compared to single-cell population media, indicating preserved bioactivity at the cellular level.

The relatively small vesicle size further supports efficient skin cell communication and absorption, contributing to visibly improved skin quality over time.

Be among the first to offer the future of cellular skin longevity.

s4S SOLUTION™ is exclusively available for licensed clinics and Med Spas ready to lead in next-level skincare. Contact us today to become a pioneering partner in cellular skin longevity.

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